ANTI-DIABETIC ACTIVITY OF MORINGO OLEIFERA

Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes

Oleifera, the widely cultivated species in 

India is an exceptionally nutritious 

vegetable with a variety of potential uses 

in treating rheumatism, venomous bites

 and microbial infections. The antidiabetic

 and antioxidant effect of methanol extracts

 of Moringa oleifera pods in streptozotocin 

(STZ)-induced diabetes in rats was studied

. Methanolic extract of M. oleifera (MOMtE)

 was studied for antidiabetic effect on 

STZ-induced diabetes on albino rats. 

The protection was measured by changes

 in biochemical parameters of serum and 

pancreas tissue. Diabetic rats were treated

 daily with different doses of MOMtE, 

i.e. 15 and 3 mg/kg b. wt./day for 21 days. 

Two phytoconstituents, quercetin and 

kaempfero

l were isolated from the MOMtE extract 

and structures were determined using 

NMR and IR spectroscopy. The data of

 present study demonstrated that the progression of diabetes significantly reduced after M

OMtE treatment. MOMtE induced a

 significant reduction in serum glucose

 and nitric oxide with

 concomitant increase in serum insulin

 and protein levels. Furthermore, MOMtE

 treatment increased the pancreas

 tissue antioxidant level with concomitant

 decrease in the level of thiobarbituric 

acid-reactive oxygen species. The histologic

 examination of pancreas of diabetic 

rats showed degenerative changes in the 

number of β-cells, while MOMtE treatment

 significantly regenerated the islets cells. 

Moringa oleifera exerts protective effect 

against STZ-induced diabetes. From present study it can be concluded that methanolic e

xtract of M. oleifera possess significant

 antidiabetic and antioxidant activity and may be considered in isolation of active cons

tituents for clinical studies.

http://scienceindex.com/stories/1972728/Evaluation_of_antidiabetic_and_antioxidant_activity_of_Moringa_oleifera_in_experimental_diabetes.htm

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