https://docs.google.com/file/d/0B47qxRp-oIjVNGNIOTRybF9sVkk/edit?usp=sharing
Effects of Oral Administration of Moringa oleifera Lam on Glucose
Tolerance in Goto-Kakizaki and Wistar Rats
Moussa Ndong, Mariko Uehara, Shin-ichi Katsumata, and Kazuharu Suzuki*
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1
Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan
Received 4 December, 2006; Accepted 27 December, 2006
Summary Medicinal plants constitute an important source of potential therapeutic agents for
diabetes. In the present study, we investigated the effects of Moringa oleifera (MO) Lam,
Moringacea, on glucose tolerance in Wistar rats and Goto-Kakizaki (GK) rats, modeled type
2 diabetes. Major polyphenols in MO powder were quercetin glucosides, rutin, kaempferol
glycosides and chlorogenic acids by HPLC analysis. As the results of glucose tolerance test, MO
significantly decreased the blood glucose at 20, 30, 45and 60 min for GK rats and at 10, 30 and
45 min for Wistar rats (p<0.05) compared to the both controls after glucose administration.
The area under the curve of changes in the blood glucose was significantly higher in the GK
control group than in the GK plus MO group (p<0.05) in the periods 30–60 min and 60–
120 min. Furthermore, MO significantly decreased stomach emptying in GK rats (p<0.05).
The results indicated that MO has an ameliorating effect for glucose intolerance, and the effect
might be mediated by quercetin-3-glucoside and fiber contents in MO leaf powder. The action
of MO was greater in GK rats than in Wistar rats.
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eHEALTH INTERNATIONAL JOURNAL
Comparative Effects of Moringa Oleifera Lam. Tea on Normal and Hyperglycemic Patients
eHEALTH INTERNATIONAL
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Comparative Effects of Moringa Oleifera Lam. Tea on Normal and
Hyperglycemic Patients
Michael Ples1 and Howell Ho1,2
1
Biology Department, De La Salle University-Manila
St. Luke’s College of Nursing, Trinity University of Asia
2
This article is available from: http://www.ehealthinternational.org/
Abstract
This study evaluates the effects on taking tea prepared from Moringa oleifera Lam.
on blood sugar levels in humans. Two groups of individuals were tested – people
with normal fasting blood sugar levels (60-120 mg/dl) and those with hyperglycemic
fasting blood sugar levels (>120 mg/dl). Among the 43 patients tested, 30 belonged
to the normal group and 13 to the hyperglycemic group. Results showed that blood
sugar levels of people in the normal group were not significantly changed 2 hours
after taking the tea. However, for hyperglycemic individuals, the blood sugar levels
significantly dropped after 2 hours. A mean drop of 28.15 mg/dl in the blood sugar
levels was observed among the hyperglycemic patients. The results point to the
benefit of using Moringa oleifera Lam. tea in the management of hyperglycemia.
BELOW IS THE STUDY
Moringa oleifera: A Review of the Medical
Evidence for Its Nutritional, Therapeutic, and
Prophylactic Properties. Part 1.
see 6 th page below.
you can see
Diabetes/hypoglycemia
with references.
Anti Diabetic Property of Drumstick (Moringa oleifera) Leaf Tablets
Abstract
The objective of this study was to formulate dehydrated green leafy tablets using drum stick leaves followed by supplementation study and to
find out the anti diabetic property on the selected diabetic patients. The results showed that post prandial blood glucose of experimental group
initially was 210 mg/dl and it reduced to 191, 174 and 150 mg/dl respectively after the first, second and third month of supplementation. In
control group post prandial blood glucose level was reduced to 169, 167, 163 mg/dl respectively, after first, second and third month of study
from the initial value of 179 mg/dl. Glycated hemoglobin in experimental group was initially 7.81 and decreased to 7.4 per cent after the
supplementation period; but in the control group it decreased to 7.36 from the initial value of 7.38 per cent. The results indicated that drum stick
leaves are suitable source of green leafy vegetable to reduce the diabetic complications in diabetic patients.
ETHNOPHARMACOLOGICAL RELEVANCE:
In Indian traditional system of medicine, Moringa oleifera Lam. Syn. Moringa pterygosperma Gaerth (Moringaceae) is commonly used as healing herb to treat diabetes. AIM OF THE STUDY: The purpose of the present study was to assess the effect of M. oleifera leaves aqueous extract therapy on glycemic control, haemoglobin, total protein, urine sugar, urine protein and body weight. MATERIALS AND METHODS: Variable doses of 100, 200 and 300 mg kg(-1) of aqueous extract were administered orally by gavage for evaluating their hypoglycemic and antidiabetic effects on fasting blood glucose (FBG), oral glucose tolerance test (OGTT) and post prandial glucose (PPG) of normal and streptozotocin (STZ) induced sub, mild and severely diabetic rats.
RESULTS:
The dose of 200 mg kg(-1) decreases blood glucose level (BGL) of normal animals by 26.7 and 29.9% during FBG and OGTT studies respectively. In sub and mild diabetic animals the same dose produced a maximum fall of 31.1 and 32.8% respectively, during OGTT. In case of severely diabetic animals FBG and PPG levels were reduced by 69.2 and 51.2% whereas, total protein, body weight and haemoglobin were increased by 11.3, 10.5 and 10.9% respectively after 21 days of treatment. Significant reduction was found in urine sugar and urine protein levels from +4 and +2 to nil and trace, respectively.
CONCLUSION:
The study validates scientifically the widely claimed use of M. oleifera as an ethnomedicine to treat diabetes mellitus.
Article Published Date : Jun 25, 2009 00
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